Divergent effects on phagocytosis by macrophage-derived oxygen radicals.

نویسندگان

  • Kelly L Brown
  • Karin Christenson
  • Anna Karlsson
  • Claes Dahlgren
  • Johan Bylund
چکیده

Clearance of senescent cells from damaged tissue is a crucial step to successfully resolve an inflammatory response. Poor clearance has been attributed to defects in neutrophil apoptosis, a process that is regulated in part by reactive oxygen species (ROS) produced by activated neutrophils. Using ROS-deficient and wild-type macrophages treated with extracellular ROS scavengers we demonstrate that macrophage-derived ROS also influence phagocytosis and do so by direct and indirect mechanisms.

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عنوان ژورنال:
  • Journal of innate immunity

دوره 1 6  شماره 

صفحات  -

تاریخ انتشار 2009